13C metabolic flux analysis-guided metabolic engineering of Escherichia coli for improved acetol production from glycerol
نویسندگان
چکیده
منابع مشابه
Production of acetol from glycerol using engineered Escherichia coli.
Escherichia coli Lin43 is a strain which has some mutations in glycerol kinase (GlpK) and the repressor for the glycerol 3-phosphate regulon (GlpR). When exposed to glycerol, it quickly accumulates lethal levels of methylglyoxal, which is a precursor of acetol; acetol is important for the manufacture of polyols, acrolein, dyes, and skin tanning agents. This work reports the engineering of E. co...
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ژورنال
عنوان ژورنال: Biotechnology for Biofuels
سال: 2019
ISSN: 1754-6834
DOI: 10.1186/s13068-019-1372-4